Method for the preparation of novel sidechain-bearing taxanes and intermediates thereof
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United States of America Patent
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Feb 4, 2003
Issued Date -
N/A
app pub date -
Jun 13, 2000
filing date -
Dec 23, 1992
priority date (Note) -
Expired
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Abstract
Methods for the preparation of sidechain-bearing taxanes, comprising the preparation of an oxazoline compound, coupling the oxazoline compound with a taxane having a hydroxyl group directly bonded at C-13 thereof to form an oxazoline sidechain-bearing taxane, and opening the oxazoline ring of the oxazoline sidechain-bearing taxane so formed. Compounds prepared by the methods of the present invention are also disclosed.
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