Growth differentiation factor-11
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United States of America Patent
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Feb 11, 2003
Grant Date -
Dec 20, 2001
app pub date -
Dec 6, 1999
filing date -
Jul 8, 1994
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Abstract
A transgenic non-human animal of the species selected from the group consisting of avian, bovine, ovine and porcine having a transgene which results in disrupting the production of and/or activity of growth differentiation factor-11 (GDF-11) chromosomally integrated into the germ cells of the animal is disclosed. Also disclosed are methods for making such animals, and methods of treating animals with antibodies or antisense directed to GDF-11. The animals so treated are characterized by increased muscle tissue.
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