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Abstract

A compound of formula (I), wherein .alpha.X is .dbd.O, .dbd.N--OR.sup.6, .beta.NHR or .beta.OH wherein R.sup.6 is H or C.sub.1 -C.sub.6 alkyl, bond a is oriented .gamma. or .delta. and R is H, C.sub.1 -C.sub.6 alkyl which is unsubstituted or substituted by C.sub.6 -C.sub.10 aryl, or C.sub.3 -C.sub.6 cycloalkyl; .epsilon. is a bond when .zeta. and .eta. are not bonds or, when X is .dbd.O, .zeta. and .eta. are both bonds and .epsilon. is not a bond; R.sup.1 and R.sup.2, which are the same or different, are H or a halogen; R.sup.3 and R.sup.4, which are the same or different, are H, C.sub.1 -C.sub.6 alkyl, C.sub.3 -C.sub.6 cycloalkyl, a heterocyclic group or an aromatic group; bond e is oriented .gamma. or .delta.; and R.sup.5 is C.sub.1 -C.sub.6 alkyl; or formula (Ib), or formula (II), or formula (III), has activity as a cytokine production inhibitor and an inhibitor and an inhibitor of tyrosine kinase. A process for producing some of the compounds from a fungal strain, processes for producing synthetic analogues from these compounds and the use of the compounds in treating immunoinflammatory and cancerous conditions are also described. ##STR1##

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