Aerosol formulations of peptides and proteins
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United States of America Patent
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Feb 25, 2003
Grant Date -
N/A
app pub date -
Apr 5, 1996
filing date -
Dec 22, 1994
priority date (Note) -
Expired
status (Latency Note)
Importance
Abstract
A pharmaceutical aerosol formulation comprising (a) a HFA propellant; (b) a pharmaceutically active polypeptide dispersible in the propellant; and (c) a surfactant which is a C.sub.8 -C.sub.16 fatty acid or salt thereof, a bile salt, a phospholipid, or an alkyl saccharide, which surfactant enhances the systemic absorption of the polypeptide in the lower respiratory tract. The invention also relates to methods of manufacturing such formulations and the use of such formulations in treating patients.
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