Recombinant megalomicin biosynthetic genes and uses thereof
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United States of America Patent
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Feb 25, 2003
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N/A
app pub date -
Oct 4, 2000
filing date -
Oct 8, 1999
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Abstract
Recombinant nucleic acids that encode all or a portion of the megAI gene of the megalomicin polyketide synthase (PKS) of Micromonospora megalomicea are used to produce recombinant PKS enzymes in host cells to make megalomicin, megalomicin derivatives, and other polyketides that are useful as antibiotics, motilides, and antiparasitics.
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