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Abstract

The present invention relates to compounds of the class of purin-2-ylcarboxamides, useful as anti-inflammatory agents, having the formula: ##STR1## and pharmaceutically acceptable salts and solvates thereof; wherein R.sup.1 is H, C.sub.1 -C .sub.6 alkyl or C.sub.3 -C.sub.7 cycloalkyl, each optionally substituted by 1 or 2 of hydroxyl, fluorenyl, or optionally substituted phenyl or naphthyl ; A is a bond or C.sub.1 -C.sub.6 alkylene; R.sup.2 is (i) H, C.sub.1 -C.sub.6 alkyl, or optionally substituted C.sub.3 -C.sub.7 cycloalkyl, phenyl, or naphthyl; or (ii) when A is C.sub.2 -C.sub.6 alkylene, --NR.sup.3 R.sup.3, --OR.sup.3, --COOR.sup.3, --OCOR.sup.4, --SO.sub.2 R.sup.4, --CN, --SO.sub.2 NR.sup.3 R.sup.4, --NR.sup.3 SO.sub.2 R.sup.4, --NR.sup.3 COR.sup.4 or --CONR.sup.3 R.sup.3 ; or (iii) a C-linked, 4 to 11 membered, mono or bicyclic heterocycle having either from 1 to 4 ring nitrogen atom(s) or 1 or 2 nitrogen and 1 oxygen or 1 sulphur ring atoms, said heterocycle being optionally C-substituted or N-substituted; or (iv) when A is C.sub.2 -C.sub.6 alkylene, optionally substituted N-linked azetidinyl, pyrrolidinyl, morpholinyl, tetrahydroisoquinolinyl, piperidinyl or piperazinyl; R.sup.7 is H, C.sub.1 -C.sub.6 alkyl, C.sub.3 -C.sub.7 cycloalkyl, phenyl, naphthyl, azetidin-3-yl, pyrrolidin-3-yl, piperidin-3-yl, piperidin-4-yl, or het; and R.sup.8 is H or C.sub.1 -C.sub.6 alkyl; and to intermediates used in processes for the preparation of, compositions containing, and uses as adenosine A2a receptor agonists of, compounds of formula (I).

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First Claim