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Abstract

Tricyclic phthalazine compounds of formula (I) ##STR1## wherein A is a 5-7 membered heterocycle containing from 1 to 4 nitrogen atoms, optionally partially or totally unsaturated, and optionally substituted by a (C.sub.1-4)alkyl group in turn optionally substituted; Z is NH, methylene, a C.sub.2-6 alkylene chain optionally branched and/or unsaturated and/or interrupted by a C.sub.5-7 cycloalkyl residue; Cy is phenyl or heterocycle optionally substituted by one or more substituents, or a COR.sub.4 group wherein R.sub.4 is hydroxy, alkoxy, amino optionally substituted by one or two (C.sub.1-6)alkyl groups or by hydroxy; R is a (C.sub.1-6)alkyl or polyfluoro(C.sub.1-6)alkyl group; R.sub.1 is hydrogen; a (C.sub.1-8)-alkyl, (C.sub.2-8)-alkenyl or (C.sub.2-8)-alkynyl group optionally substituted by hydroxy, oxo, aryl or heterocycle, and optionally interrupted by one or more heteroatoms or heterogroups; a (C.sub.1-4)alkoxy group or a (C.sub.4-7)cycloalkoxy group optionally containing an oxygen atom and optionally substituted by a polar substituent in the cyclic moiety, aryloxy aryl-(C.sub.1-10)-alkoxy; the N--O derivatives and the pharmaceutically acceptable salts thereof are described. The compounds of formula (I) are PDE 4 inhibitors.

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