US Patent No: 6,528,526

Number of patents in Portfolio can not be more than 2000

Quinoline and quinoxaline compounds which inhibit platelet-derived growth factor and/or p56lck tyrosine kinases

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ATTORNEY / AGENT: (SPONSORED)
 

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Abstract

This invention is directed to quinoline/quinoxaline compounds which inhibit platelet-derived growth factor or p56.sup.lck tyrosine kinase activity, to pharmaceutical compositions comprising these compounds, and to the use of these compounds for treating a patient suffering from or subject to disorders/conditions involving cellular differentiation, proliferation, extracellular matrix production or mediator release and/or T cell activation and proliferation.

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First Claim

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Patent Owner(s)

Patent OwnerAddressTotal Patents
AVENTIS PHARMACEUTICALS INC.BRIDGEWATER, NJ256

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
He, Wei Beijing, CN 115 937
Maguire, Martin P Woburn, MA 32 1306
Myers, Michael R Fishers, IN 48 1970
Spada, Alfred P Lansdale, PA 61 2158

Cited Art

Patent Info (Count) # Cites Year
 
ADVANCED CARDIOVASCULAR SYSTEMS, INC. (3)
5,637,113 Polymer film for wrapping a stent structure 365 1994
5,605,696 Drug loaded polymeric material and method of manufacture 528 1995
5,700,286 Polymer film for wrapping a stent structure 525 1996
 
RHONE-POULENC RORER PHARMACEUTICALS INC. (2)
5,480,883 Bis mono- and bicyclic aryl and heteroaryl compounds which inhibit EGF and/or PDGF receptor tyrosine kinase 123 1993
5,646,153 Bis mono- and bicyclic aryl and heteroaryl compounds which inhibit EGF and/or PDGF receptor tyrosine kinase 75 1995
 
AVENTIS PHARMACEUTICALS INC. (1)
5,409,930 Bis mono- and bicyclic aryl and heteroaryl compounds which inhibit EGF and/or PDGF receptor tyrosine kinase 120 1993
 
BAYER AKTIENGESELLSCHAFT (1)
5,650,514 3-substituted quinoline-5-carboxylic acid derivatives and processes for their preparation 8 1995
 
Biosignal L.T.D. (1)
5,700,823 Treatment of platelet derived growth factor related disorders such as cancers 43 1994
 
CORDIS CORPORATION (1)
5,336,518 Treatment of metallic surfaces using radiofrequency plasma deposition and chemical attachment of bioactive agents 128 1992
 
MED INSTITUTE, INC. (1)
5,824,049 Coated implantable medical device 665 1996
 
MERCK FROSST CANADA & CO. (1)
4,661,499 2-[(substituted)-phenoxymethyl]quinolines 43 1985
 
SUGEN, INC. (1)
5,760,066 Compounds and methods for inhibiting hyper-proliferative cell growth 16 1996

Patent Citation Ranking

Forward Cites

Patent Info (Count) # Cites Year
 
ADVANCED CARDIOVASCULAR SYSTEMS, INC. (100)
7,682,669 Methods for covalently immobilizing anti-thrombogenic material into a coating on a medical device 1 2001
8,303,651 Polymeric coating for reducing the rate of release of a therapeutic substance from a stent 0 2001
7,217,426 Coatings containing polycationic peptides for cardiovascular therapy 18 2002
7,070,798 Coatings for implantable medical devices incorporating chemically-bound polymers and oligomers of L-arginine 14 2002
7,056,523 Implantable medical devices incorporating chemically conjugated polymers and oligomers of L-arginine 7 2002
7,033,602 Polycationic peptide coatings and methods of coating implantable medical devices 11 2002
7,011,842 Polycationic peptide coatings and methods of making the same 7 2002
6,994,867 Biocompatible carrier containing L-arginine 34 2002
7,776,926 Biocompatible coating for implantable medical devices 19 2002
7,094,256 Coatings for implantable medical device containing polycationic peptides 22 2002
7,258,891 Stent mounting assembly and a method of using the same to coat a stent 13 2003
7,279,174 Stent coatings comprising hydrophilic additives 45 2003
7,198,675 Stent mandrel fixture and method for selectively coating surfaces of a stent 47 2003
6,953,560 Barriers for polymer-coated implantable medical devices and methods for making the same 49 2003
7,261,946 Block copolymers of acrylates and methacrylates with fluoroalkenes 7 2003
8,192,752 Coatings for implantable devices including biologically erodable polyesters and methods for fabricating the same 0 2003
7,220,816 Biologically absorbable coatings for implantable devices based on poly(ester amides) and methods for fabricating the same 32 2003
7,435,788 Biobeneficial polyamide/polyethylene glycol polymers for use with drug eluting stents 5 2003
7,563,324 System and method for coating an implantable medical device 20 2003
7,014,913 Rate-reducing membrane for release of an agent 7 2004
7,758,880 Biocompatible polyacrylate compositions for medical applications 0 2004
7,364,748 Controlled morphologies in polymer drug for release of drugs from polymer films 2 2004
7,807,210 Hemocompatible polymers on hydrophobic porous polymers 0 2004
7,553,377 Apparatus and method for electrostatic coating of an abluminal stent surface 6 2004
8,293,890 Hyaluronic acid based copolymers 0 2004
7,820,732 Methods for modulating thermal and mechanical properties of coatings on implantable devices 0 2004
7,785,512 Method and system of controlled temperature mixing and molding of polymers with active agents for implantable medical devices 6 2004
7,807,211 Thermal treatment of an implantable medical device 4 2004
7,563,780 Heparin prodrugs and drug delivery stents formed therefrom 3 2004
7,077,860 Method of reducing or eliminating thrombus formation 14 2004
7,297,159 Selective coating of medical devices 3 2004
8,357,391 Coatings for implantable devices comprising poly (hydroxy-alkanoates) and diacid linkages 0 2004
7,494,665 Polymers containing siloxane monomers 2 2004
7,311,980 Polyactive/polylactic acid coatings for an implantable device 8 2004
7,648,727 Methods for manufacturing a coated stent-balloon assembly 0 2004
7,244,443 Polymers of fluorinated monomers and hydrophilic monomers 6 2004
8,110,211 Medicated coatings for implantable medical devices including polyacrylates 0 2004
8,052,912 Temperature controlled crimping 0 2004
7,166,680 Blends of poly(ester amide) polymers 15 2004
7,481,835 Encapsulated covered stent 4 2004
7,390,497 Poly(ester amide) filler blends for modulation of coating properties 9 2004
7,214,759 Biologically absorbable coatings for implantable devices based on polyesters and methods for fabricating the same 8 2004
7,892,592 Coating abluminal surfaces of stents and other implantable medical devices 0 2004
7,632,307 Abluminal, multilayer coating constructs for drug-delivery stents 3 2004
7,604,818 Polymers of fluorinated monomers and hydrocarbon monomers 0 2004
7,419,504 Poly(ester amide) block copolymers 4 2004
8,007,775 Polymers containing poly(hydroxyalkanoates) and agents for use with medical articles and methods of fabricating the same 2 2004
7,202,325 Poly(hydroxyalkanoate-co-ester amides) and agents for use with medical articles 17 2005
7,387,810 Method of forming rate limiting barriers for implantable devices 6 2005
7,063,884 Stent coating 16 2005
7,758,881 Anti-proliferative and anti-inflammatory agent combination for treatment of vascular disorders with an implantable medical device 1 2005
7,700,659 Implantable devices formed of non-fouling methacrylate or acrylate polymers 5 2005
7,795,467 Bioabsorbable, biobeneficial polyurethanes for use in medical devices 3 2005
7,637,941 Endothelial cell binding coatings for rapid encapsulation of bioerodable stents 17 2005
7,691,401 Poly(butylmethacrylate) and rapamycin coated stent 20 2005
7,622,070 Method of manufacturing an implantable polymeric medical device 5 2005
7,823,533 Stent fixture and method for reducing coating defects 0 2005
8,021,676 Functionalized chemically inert polymers for coatings 3 2005
8,067,023 Implantable medical devices incorporating plasma polymerized film layers and charged amino acids 0 2005
7,785,647 Methods of providing antioxidants to a drug containing product 0 2005
7,735,449 Stent fixture having rounded support structures and method for use thereof 6 2005
7,875,286 Polycationic peptide coatings and methods of coating implantable medical devices 0 2005
7,803,406 Polycationic peptide coatings and methods of coating implantable medical devices 0 2005
7,794,743 Polycationic peptide coatings and methods of making the same 0 2005
7,985,440 Method of using a mandrel to coat a stent 1 2005
7,396,541 Heparin prodrugs and drug delivery stents formed therefrom 2 2005
7,976,891 Abluminal stent coating apparatus and method of using focused acoustic energy 1 2005
7,591,841 Implantable devices for accelerated healing 0 2005
7,867,547 Selectively coating luminal surfaces of stents 0 2005
7,638,156 Apparatus and method for selectively coating a medical article 20 2005
7,601,383 Coating construct containing poly (vinyl alcohol) 1 2006
7,713,637 Coating containing PEGylated hyaluronic acid and a PEGylated non-hyaluronic acid polymer 1 2006
8,304,012 Method for drying a stent 0 2006
8,069,814 Stent support devices 1 2006
8,003,156 Rotatable support elements for stents 1 2006
7,648,725 Clamp mandrel fixture and a method of using the same to minimize coating defects 1 2006
7,572,336 Clamp mandrel fixture and a method of using the same to minimize coating defects 2 2006
7,775,178 Stent coating apparatus and method 0 2006
8,114,150 RGD peptide attached to bioabsorbable stents 1 2006
7,357,793 Polymers of fluorinated and hydrophilic monomers 17 2006
8,173,199 40-O-(2-hydroxy)ethyl-rapamycin coated stent 0 2006
7,803,394 Polycationic peptide hydrogel coatings for cardiovascular therapy 0 2006
7,875,073 Block copolymers of acrylates and methacrylates with fluoroalkenes 0 2006
7,365,133 Blends of poly(ester amide) polymers 0 2006
8,017,141 Coatings of acrylamide-based copolymers 0 2006
8,197,879 Method for selectively coating surfaces of a stent 0 2007
7,604,700 Stent mandrel fixture and method for selectively coating surfaces of a stent 1 2007
7,361,726 Poly(hydroxyalkanoate-co-ester amides) and agents for use with medical articles 3 2007
8,067,025 Nitric oxide generating medical devices 0 2007
7,538,180 Biologically absorbable coatings for implantable devices based on poly(ester amides) and methods for fabricating the same 0 2007
7,901,703 Polycationic peptides for cardiovascular therapy 0 2007
8,017,140 Drug-delivery stent formulations for restenosis and vulnerable plaque 0 2007
7,766,884 Polymers of fluorinated monomers and hydrophilic monomers 0 2007
7,520,891 Blends of poly(ester amide) polymers 1 2008
7,507,251 Blends of poly(ester amide) polymers 0 2008
7,699,889 Poly(ester amide) block copolymers 0 2008
7,786,249 Biobeneficial polyamide/polyethylene glycol polymers for use with drug eluting stents 0 2008
7,772,359 Biobeneficial polyamide/polyethylene glycol polymers for use with drug eluting stents 0 2008
7,632,914 Biobeneficial polyamide/polyethylene glycol polymers for use with drug eluting stents 0 2008
8,293,367 Nanoshells on polymers 0 2011
 
ABBOTT CARDIOVASCULAR SYSTEMS INC. (15)
7,985,441 Purification of polymers for coating applications 1 2006
8,048,448 Nanoshells for drug delivery 0 2006
8,017,237 Nanoshells on polymers 0 2006
7,569,655 Biologically absorbable coatings for implantable devices based on polyesters and methods for fabricating the same 1 2007
8,029,816 Medical device coated with a coating containing elastin pentapeptide VGVPG 8 2007
8,147,769 Stent and delivery system with reduced chemical degradation 0 2007
8,109,904 Drug delivery medical devices 0 2007
8,048,441 Nanobead releasing medical devices 0 2007
7,713,541 Zwitterionic terpolymers, method of making and use on medical devices 8 2007
7,749,263 Poly(ester amide) filler blends for modulation of coating properties 0 2008
8,118,863 RGD peptide attached to bioabsorbable stents 0 2008
8,062,350 RGD peptide attached to bioabsorbable stents 0 2008
8,435,550 Anti-proliferative and anti-inflammatory agent combination for treatment of vascular disorders with an implantable medical device 0 2008
8,431,665 Zwitterionic terpolymers, method of making and use on medical devices 0 2010
8,333,984 Coatings of acrylamide-based copolymers 0 2011
 
ABBOTT LABORATORIES (10)
8,101,156 Methods of manufacturing copolymers with zwitterionic moieties and dihydroxyphenyl moieties and use of same 1 2007
8,063,151 Methods for manufacturing copolymers having 1-methyl-2-methoxyethyl moieties and use of same 1 2007
7,928,176 Copolymers having zwitterionic moieties and dihydroxyphenyl moieties and medical devices coated with the copolymers 6 2007
7,928,177 Amino acid mimetic copolymers and medical devices coated with the copolymers 6 2007
7,910,678 Copolymers having 1-methyl-2-methoxyethyl moieties 7 2007
7,781,551 Zwitterionic copolymers, method of making and use on medical devices 4 2007
8,399,584 Copolymers having zwitterionic moieties and dihydroxyphenyl moieties and medical devices coated with the copolymers 0 2011
8,202,956 Copolymers having zwitterionic moieties and dihydroxyphenyl moieties and medical devices coated with the copolymers 2 2011
8,071,705 Amino acid mimetic copolymers and medical devices coated with the copolymers 1 2011
8,048,975 Amino acid mimetic copolymers and medical devices coated with the copolymers 2 2011
 
AVENTIS PHARMACEUTICALS INC. (1)
6,852,712 Quinoline and quinoxaline compounds which inhibit platelet-derived growth factor and/or p56lck tyrosine kinases 1 2003
 
ORBUSNEICH MEDICAL, INC. (1)
8,088,060 Progenitor endothelial cell capturing with a drug eluting implantable medical device 0 2006

Maintenance Fees

Fee Large entity fee small entity fee micro entity fee due date
11.5 Year Payment $7400.00 $3700.00 $1850.00 Sep 4, 2014
Fee Large entity fee small entity fee micro entity fee
Surcharge - 11.5 year - Late payment within 6 months $160.00 $80.00 $40.00
Surcharge after expiration - Late payment is unavoidable $700.00 $350.00 $175.00
Surcharge after expiration - Late payment is unintentional $1,640.00 $820.00 $410.00