Oligonucleotide-folate conjugates
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United States of America Patent
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Mar 4, 2003
Issued Date -
N/A
app pub date -
Jun 16, 1998
filing date -
Sep 3, 1993
priority date (Note) -
Expired
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Abstract
Oligonucleotide-folate conjugates are described wherein folates are conjugated to one or more sites on an oligonucleotide including the 2'-, 3'-, 5'-, nucleobase and internucleotide linkage sites. The folate can be attached via the .alpha.- or .gamma.-carboxylate, optionally through a linking group. Methods for the regiospecific synthesis of the conjugates are disclosed.
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