Single isomer methylphenidate and resolution process
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United States of America Patent
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Mar 11, 2003
Grant Date -
Aug 16, 2001
app pub date -
Apr 17, 2001
filing date -
Jan 22, 1996
priority date (Note) -
Expired
status (Latency Note)
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Abstract
Single isomer methylphenidate, selected from the d- and l-threo-enantiomers, has been obtained in purified form, to the extent of less than 2% by weight of a contaminant selected from resolving agent and ritalinic acid. This is achieved by resolution of a mixture of enantiomers using an O, O'-diaroyltartaric acid as resolving agent.
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