Anti-.alpha.v.beta.3 recombinant human antibodies and nucleic acids encoding same
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United States of America Patent
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Mar 11, 2003
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app pub date -
Jun 24, 1999
filing date -
Jun 24, 1999
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Abstract
The invention provides enhanced LM609 grafted antibodies exhibiting selective binding affinity to .alpha..sub.V.beta..sub.3, or a functional fragment thereof. The invention also provides nucleic acid molecules encoding the enhanced LM609 grafted antibodies. Additionally provided are methods of inhibiting a function of .alpha..sub.V.beta..sub.3 by contacting .alpha..sub.V.beta..sub.3 with an enhanced LM609 grafted antibody.
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