Processes for the synthesis of oligonucleotide compounds
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United States of America Patent
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Mar 11, 2003
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N/A
app pub date -
Apr 24, 1998
filing date -
Apr 24, 1998
priority date (Note) -
Expired
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Abstract
Methods for the preparation of oligonucleotides having bioreversible phosphate blocking groups are disclosed. The oligonucleotides are prepared utilizing amidite type chemistry wherein the bioreversible phosphorus protecting group is formed as an integral part of the amidite reagent.
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