Biological materials and methods useful in the diagnosis and treatment of diseases
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United States of America Patent
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Mar 18, 2003
Grant Date -
N/A
app pub date -
Nov 2, 1999
filing date -
Nov 4, 1998
priority date (Note) -
Expired
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Abstract
The present invention relates to a method of making a .beta.-form of a prion protein which preferably has more .beta.-sheet than .alpha.-helix structure and is soluble in the absence of a denaturant and/or is non-aggregated and exhibits partial resistance to digestion with proteinase K. The invention also relates to use of the .beta.-form in medicine, especially for raising antibodies useful in the treatment and/or diagnosis of prion diseases. The invention also relates to methods of screening for compounds which are capable of inhibiting and/or reversing the conversion of the native .alpha.-form of a prion protein to a .beta.-form, and to uses of identified compounds in medicine.
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