Oligonucleotide inhibition of protein kinase C

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United States of America Patent

PATENT NO 6537973
SERIAL NO

10025139

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Abstract

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Compositions and methods are provided for the treatment and diagnosis of diseases associated with protein kinase C. Oligonucleotides are provided which are targeted to nucleic acids encoding PKC. In preferred embodiments, the oligonucleotides contain one or more chemical modifications. Methods of modulating PKC expression and of treating animals suffering from disease amenable to therapeutic intervention by modulating protein kinase C expression using oligonucleotides targeted to PKC are disclosed.

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Patent Owner(s)

Patent OwnerAddress
ISIS PHARMACEUTICALS INC2280 FARADAY AVENUE CARLSBAD CA 92008 UNITED STATES OF AMERICA

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Bennett, C Frank Carlsbad, CA 412 7677
Dean, Nicholas M Olivenhain, CA 126 2851
Dorr, F Andrew Solana Beach, CA 9 45
Holmlund, Jon T Carlsbad, CA 5 36

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