Continuous adherent melanocyte cell line
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United States of America Patent
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Apr 1, 2003
Grant Date -
Jan 17, 2002
app pub date -
Apr 18, 2001
filing date -
Jun 22, 2000
priority date (Note) -
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Abstract
The present invention comprises a novel immortal non-adherent human melanocyte cell line, designated WC-1 14.07. This cell line is stable and MHC class I negative. This continuous melanocyte cell line can be used as a source of melanin and hgp100. The Class I MHC-negative nature of this cell line allows it to be used as a target for transfection with MHC class I genes, providing a novel source of hgp100 in a pre-determined MHC context. The cell line can thus be used in a variety of ways, directly or indirectly, in the development and manufacture of vaccines for melanoma.
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