Methods for solid-phase synthesis of hydroxylamine compounds and derivatives and combinatorial libraries thereof

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United States of America Patent

PATENT NO 6541276
APP PUB NO 20010053555A1
SERIAL NO

08958638

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Abstract

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A novel method for generating hydroxylamine, hydroxamic acid, hydroxyurea, and hydroxylsulfonamide compounds is disclosed. The method involves the nucleophilic attack of an alkoxyamine on a suitable solid phase support. Techniques of combinatorial chemistry can then be applied to the immobilized alkoxyamine to generate a diverse set of compounds. Cleavage of the compounds from the support yields a library of hydroxylamine or hydroxylamine derivative compounds, which can be screened for biological activity (e.g., inhibition of metalloproteases).

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Patent Owner(s)

Patent OwnerAddress
VERSICOR INC34790 ARDENTECH COURT FREMONT CA 94555

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Ngu, Khehyong Palo Alto, CA 31 158
Patel, Dinesh V Fremont, CA 71 1372

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