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Abstract

The present invention of compounds of formula (I) ##STR1## a stereochemically isomeric form thereof, an N-oxide form thereof or a pharmaceutically acceptable acid addition salt thereof, --R.sup.1 --R.sup.2 -- is a bivalent radical of formula wherein in said bivalent radicals one or two hydrogen atoms may be substituted with C.sub.1-6 alkyl or hydroxy; R.sup.3 is hydrogen or halo; R.sup.4 is hydrogen or C.sub.1-6 alkyl; R.sup.5 is hydrogen or C.sub.1-6 alkyl; L is C.sub.3-6 cycloalkyl, oxoC.sub.5-6 cycloalkyl, C.sub.2-6 alkenyl, or L is a radical of formula --Alk--R.sup.6 --, Alk--X--R.sup.7, --Alk--Y--C(.dbd.O)--R.sup.9, or --Alk--Y--C(.dbd.O)--NR.sup.11 R.sup.12 wherein each Alk is C.sub.1-12 alkanediyl; and R.sup.6 is hydrogen, amino, cyano, C.sub.1-6 alkylsulfonylamino, C.sub.3-6 cycloalkyl, oxoC.sub.5-6 cycloalkyl, aryl or a heterocyclic ringsystem; R.sup.7 is hydrogen, C.sub.1-6 alkyl, hydroxyC.sub.1-6 alkyl, C.sub.3-6 cycloalkyl, aryl or a heterocyclic ringsystem; X is O, S, SO.sub.2 or NR.sup.8 ; said R.sup.8 being hydrogen or C.sub.1-6 alkyl; R.sup.9 is hydrogen, C.sub.1-6 alkyl, C.sub.3-6 cycloalkyl, C.sub.1-6 alkyloxy, hydroxy or aryl; Y is a direct bond or NR.sup.10 ; said R.sup.10 being hydrogen, or C.sub.1-6 alkyl; R.sup.11 and R.sup.12 each independently are hydrogen, C.sub.1-6 alkyl, C.sub.3-6 cycloalkyl, or R.sup.11 and R.sup.12 combined with the nitrogen atom may form an optionally substituted pyrrolidinyl, piperidinyl, piperazinyl or 4-morpholinyl ring. Processes for preparing said products, formulations comprising said products and their use as a medicine are disclosed, in particular for treating or preventing gastrointestinal disorders.

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First Claim