Inhibition of molecular and biological processes using modified oligonucleotides
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United States of America Patent
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Apr 15, 2003
Grant Date -
N/A
app pub date -
Sep 5, 2000
filing date -
Sep 5, 2000
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Expired
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Abstract
A method of inhibiting at least one molecular process in a sample, comprising administering to the sample an oligonucleotide or polynucleotide containing at least one monomeric unit having formula (I): A--X.sub.n (I) wherein A is an organic moiety, n is at least 1, and each X is independently selected from the group consisting of --NRCOCONu, --NHCOCR.sub.2 CR.sub.2 CONu, --NHCOCR.dbd.CRCONu, and --NHCOSSCONu, wherein each R independently represents H or a substituted or unsubstituted alkyl group, and Nu represents a nucleophile, or a salt of the compound.
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