Attachment of oligonucleotides to solid supports through schiff base type linkages for capture and detection of nucleic acids
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United States of America Patent
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Apr 15, 2003
Issued Date -
N/A
app pub date -
Feb 9, 2001
filing date -
Jul 29, 1999
priority date (Note) -
Expired
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Abstract
Derivatized oligonucleotides (ODNs) are coupled to a solid support in improved yield resulting in a high density of coupled oligonucleotide per surface unit of the support, through a Schiff base type bond formed between an NH.sub.2 group attached either to the solid support or to the ODN and an aromatic aldehyde attached to the other of the solid support and the ODN. The preferred solid support-ODN conjugate is formed between semicarbazide groups attached to a glass surface and an aromatic aldehyde attached at either 3', or 5' end of an ODN or to an intermediate nucleotide of the ODN.
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