Production of heterologous protein in milk of transgenic non-human mammals comprising a construct with an intron

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United States of America Patent

PATENT NO 6548735
SERIAL NO

08781518

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Abstract

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Proteinaceous products can be produced by transgenic animals having genetic constructs integrated into their genome. The construct comprises a 5'-flanking sequence from a mammalian milk protein gene (such as beta-lactoglobulin) and DNA coding for a heterologous protein other than the milk protein (for example a serin protease such as alpha.sub.1 -antitrypsin or a blood factor such as Factor VIII or IX). The protein-coding DNA comprises at least one, but not all, of the introns naturally occurring in a gene coding for the heterologous protein. The 5'-flanking sequence is sufficient to drive expression of the heterologous protein.

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Patent Owner(s)

Patent OwnerAddress
KING GEORGE HOLDINGS LUXEMBOURG IIA S A R L174 ROUTE DE LONGWY LUXEMBOURG L-1940

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Archibald, Alan Langskill Edinburgh, GB 4 8
Clark, Anthony John Midlothian, GB 31 327

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