Methods for making polyketides
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United States of America Patent
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Apr 22, 2003
Grant Date -
Dec 13, 2001
app pub date -
Dec 12, 2000
filing date -
Jul 2, 1998
priority date (Note) -
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Abstract
The stereochemical centers of a polyketide can be changed by replacement of ketosynthase domains in the polyketide synthase (PKS) enzyme that produces the polyketide. The specificity of the AT domains of a PKS is determined by a hypervariable region that can be replaced or altered to change the specificity of the AT domain from a naturally occurring extender unit to another naturally or non-naturally occurring extender unit. Non-naturally occurring extender units, including methylmalonyl N-acetyl cysteamine thioester can be incorporated into polyketides in recombinant host cells or in cell-free systems to make polyketides.
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