Use of background electrolytes to minimize flux variability during iontophoresis
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United States of America Patent
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Apr 22, 2003
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N/A
app pub date -
Oct 27, 2000
filing date -
Oct 27, 2000
priority date (Note) -
Expired
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Abstract
A device and method are provided that minimize the changes in flux encountered during iontophoresis and reduce inter-subject variability. For drug delivery, the active agent to be delivered is administered in conjunction with at least one background ion having a hindrance factor that changes at a faster rate than the hindrance factor of the active agent when an electrical current is applied. For analyte extraction, the extraction reservoir contains at least one background ion having a hindrance factor that changes at a faster rate than the hindrance factor of the background ions of the analyte in the tissue when an electrical current is applied.
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