Preparation of micron-size pharmaceutical particles by microfluidization
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United States of America Patent
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Apr 29, 2003
Grant Date -
Jun 13, 2002
app pub date -
Jun 28, 1999
filing date -
Jun 28, 1999
priority date (Note) -
Expired
status (Latency Note)
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Abstract
The present invention relates to a process of microfluidization or wet-micronization of hydrophobic drugs in combination with dextrins such as .beta.-cyclodextrin. The microfluidized particles are useful in controlled swellability, erosion rate-controlled drug delivery systems. The process of microfluidization facilitates reduction of mean particle size of slightly soluble but highly permeable drugs and creates a smooth, latex-like micro-suspension. A blend of swellable polymer and insoluble, hydrophilic excipients granulated with the micro-suspension create a swellable matrix that after compaction erodes uniformly over a 24-hour period. Optimization of drug release is achieved by modification of the geometry of the drug delivery system.
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