Methods for identifying human cell lines useful for endogenous gene activation isolated human cell lines identified thereby, and uses thereof
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United States of America Patent
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Apr 29, 2003
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Jun 30, 2000
filing date -
Jul 23, 1997
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Abstract
The invention concerns human cells which, due to an activation of the endogenous human EPO gene, are able to produce EPO in an adequate quantity and purity to enable a cost-effective production of human EPO as a pharmaceutical preparation. Furthermore the invention concerns a process for the production of such human EPO-producing cells, DNA constructs for the activation of the endogenous EPO gene in human cells as well as a process for the large-scale production of EPO in human cells.
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