Mutant human hepatitis B viral strain and uses thereof
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United States of America Patent
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May 6, 2003
Grant Date -
N/A
app pub date -
Apr 30, 2001
filing date -
Jun 19, 1998
priority date (Note) -
Expired
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Abstract
An isolated strain of Hepatitis B virus designated Human Hepatitis B Virus Surface Antigen-`S`-133 Oon Strain (Methionine to Threonine) of Cell. Also, an isolated nucleic acid encoding a polypeptide which is a mutant major surface antigen of a strain of hepatitis B virus, such polypeptide having an amino acid sequence which differs from the amino acid sequence of a major surface antigen of a wild type hepatitis B virus in that the amino acid at position number 133 of such polypeptide is a threonine rather than methionine.
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