Methods of screening potential translational regulatory elements of messenger RNA
Number of patents in Portfolio can not be more than 2000
United States of America Patent
Stats
-
May 6, 2003
Grant Date -
Jul 4, 2002
app pub date -
Mar 26, 2001
filing date -
Sep 25, 2000
priority date (Note) -
Expired
status (Latency Note)
Importance
Abstract
The present invention relates to a method of screening a potential translational regulatory element of mRNA, which promotes or suppresses the translation efficiency of mRNA in a given translation system, by applying the in vitro evolution principles. Specifically, the present invention relates to a method of screening a potential translational regulatory element of mRNA, comprising the steps of synthesizing mRNAs with random oligonucleotide sequences, which are candidates of translational regulatory elements, introduced into the untranslated regions (UTRs), and selecting mRNAs with altered translation efficiency by virtue of the inserted motifs; to translational regulatory elements screened by this method; and to a method of isolating mRNA with altered translation efficiency in comparison with the native mRNA by using such a screening method.
First Claim
Family
International Classification(s)
Cited Art Landscape
Patent Citation Ranking
Advertisement
Advertisement
Advertisement
Recipient Email Address
Recipient Email Address
Comment
Recipient Email Address
Add to Portfolio(s)
To add this patent to one, or more, of your portfolios, simply click the add button.
This Patent is in these Portfolios:
Add to additional portfolios:
Last Refreshed On:
Changes done successfully