Combinatorial polyketide libraries produced using a modular PKS gene cluster as scaffold
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United States of America Patent
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May 6, 2003
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N/A
app pub date -
May 6, 1998
filing date -
May 6, 1994
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Abstract
Combinatorial libraries of polyketides can be obtained by suitable manipulation of a host modular polyketide synthase gene cluster such as that which encodes the PKS for erythromycin. The combinatorial library is useful as a source of pharmaceutically active compounds. In addition, novel polyketides and antibiotics are prepared using this method.
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