Transdermal administration of androgenic drugs hydroxide-releasing agents as permeation enhancers
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United States of America Patent
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May 13, 2003
Grant Date -
Nov 1, 2001
app pub date -
Dec 14, 2000
filing date -
Dec 16, 1999
priority date (Note) -
Expired
status (Latency Note)
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Abstract
A method is provided for increasing the permeability of skin or mucosal tissue to transdermally administered androgenic drugs. The method involves use of a specified amount of a hydroxide-releasing agent, the amount optimized to increase the flux of the androgenic drug through a body surface while minimizing the likelihood of skin damage, irritation or sensitization. Formulations and drug delivery systems for co-administering a hydroxide-releasing agent with an androgenic drug are provided as well.
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