Decreasing cell proliferation by decreasing levels of PP5
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United States of America Patent
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May 13, 2003
Issued Date -
N/A
app pub date -
Aug 28, 2000
filing date -
Nov 20, 1997
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Abstract
The invention provides a method of increasing expression of p21.sup.WAF1/Cip 1 in cells to decrease proliferation of the cells, the method comprising decreasing levels of PP5 protein in the cells. The invention further provides a method of treating or preventing an abnormal condition resulting from a defect in a tumor suppressor gene in a subject that results in decreased induction of p21.sup.WAF1/Cip 1 in the cells of the subject, the method comprising administering to the subject an amount of a compound effective to decrease levels of PP5 protein in the cells of the subject.
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