Microcapsules for administration of neuroactive agents
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United States of America Patent
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May 20, 2003
Grant Date -
Jul 18, 2002
app pub date -
Aug 21, 2001
filing date -
May 16, 1990
priority date (Note) -
Expired
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Abstract
The present invention relates to polymeric microspheres as injectable, drug-delivery vehicles for use to deliver bioactive agents to sites within the central nervous system, and for the stimulation of nerve fiber growth by implanting such microspheres within the central nervous system of a patient. Microspheres of less than 45 .mu.m, preferably less than about 20 .mu.m, and preferably about 0.1 .mu.m to about 10 .mu.m in mean diameter according to the present invention are also selectively taken-up and into astrocytes when delivered directly into the nervous tissues.
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