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Abstract

A process for the preparation of N-substituted-hydroxycycloalkylamine derivatives, that are useful intermediates for the synthesis of various organic chemicals including pharmaceutical and agrochemical compounds, represented by formula (1), by reacting a 1,2-dihydroxalkyl alcohol, represented by the following formula (2), with a thionyl halide to produce an intermediate 1,2-cyclosulfinylalkyl halide represented by the following formula (3); and then cyclizing that intermediate with an amine compounds represented by the following formula (4). ##STR1## In the above structural formuli, * represents an asymmetric carbon atom; R.sub.1 is hydrogen or an amino-protecting group; m is an integer of 1-3; and X is halogen. The reactant compounds as well as the compounds made according to this invention have the following substitution pattern: n=1, R.sub.2 =OH, R.sub.3 =H and m=1; n=1, R.sub.2 =H, R.sub.3 =CH.sub.2 OH and m=2; n=2, R.sub.2 =OH, R.sub.3 =H; and m=2; and n=2, R.sub.2 =H, R.sub.3 =CH.sub.2 OH and m=3.

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First Claim