Inhaleable spray dried 4-helix bundle protein powders having minimized aggregation
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United States of America Patent
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May 27, 2003
Grant Date -
May 30, 2002
app pub date -
Aug 7, 2001
filing date -
Aug 7, 2000
priority date (Note) -
Expired
status (Latency Note)
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Abstract
The present invention provides highly dispersible spray-dried powder compositions, and in particular, inhaleable dry powder compositions for aerosolized delivery to the lungs. The powders of the invention are produced by spray drying a 4 .alpha.-helix bundle protein under conditions which both (i) protect the protein from aggregation and (ii) provide particles suitable for inhalation (i.e., demonstrating superior aerosol performance).
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