Methods for multiple direct label probe detection of multiple chromosomes or regions thereof by in situ hybridization
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United States of America Patent
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May 27, 2003
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Jun 21, 2001
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Sep 20, 1990
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Abstract
Direct label probe compositions which stain DNA of a preselected single chromosome or region of a chromosome of a multi-chromosomal genome are provided that comprise mixed DNA segments which are covalently bound to fluorophore groups through linking groups. The mixed DNA segments are derived from the DNA present in the preselected chromosome or chromosome region. These probe compositions can be used concurrently or sequentially with other probe compositions.
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