Method for screening compounds for the treatment of neoplasia
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United States of America Patent
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May 27, 2003
Grant Date -
N/A
app pub date -
Mar 3, 2000
filing date -
Mar 3, 2000
priority date (Note) -
Expired
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Abstract
This invention provides a method to identify compounds potentially useful for the treatment and prevention of neoplasia in mammals. The phosphodiesterase inhibitory activity of a compound is determined along with its ability to elevate JNK kinase activity. Growth inhibitory and apoptosis inducing effects on cultured tumor cells are also determined. Compounds that exhibit phosphodiesterase inhibition, an ability to elevate JNK kinase activity, growth inhibition and apoptosis induction are desirable for the treatment of neoplasia.
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