Method and apparatus for real-time control of physiological parameters
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United States of America Patent
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Jun 3, 2003
Issued Date -
N/A
app pub date -
Sep 21, 2001
filing date -
Sep 22, 2000
priority date (Note) -
Expired
status (Latency Note)
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Abstract
A real-time controller operating as an artificial pancreas uses a Kalman control algorithm to control glucose level of a patient in real time. The real-time controller receives an estimate of the patient glucose level and a reference glucose level. The estimate of the patient glucose level can be provided by an optimal estimator implemented using a linearized Kalman filter. The estimated glucose level and the reference glucose level are processed by the Kalman control algorithm to determine a control command in real time. The Kalman control algorithm has a dynamic process forced by the control command a cost function determining a relative level of control. The control command is provided to a dispenser which secretes insulin or glucagon in response to the control command to correct a relatively high glucose level or a relatively low glucose level.
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