Ribozymes having 2'-O substituted nucleotides in the flanking sequences
Number of patents in Portfolio can not be more than 2000
United States of America Patent
Stats
-
Jun 3, 2003
Issued Date -
N/A
app pub date -
Oct 13, 2000
filing date -
Feb 26, 1992
priority date (Note) -
Expired
status (Latency Note)
Importance
Abstract
The present invention provides methods for increasing ribozyme catalytic activity without reducing specificity, which methods comprise contacting an RNA molecule with a ribozyme having a flanking sequence modified to contain 2'-O-substituted nucleotides. The invention also provides ribozymes comprising a flanking sequence modified to contain 2'-O-substituted nucleotides. In addition, the invention provides methods for increasing ribozyme catalytic activity comprising contacting an RNA molecule with a ribozyme having a flanking sequence modified to contain a 2'-O-substituted nucleotide and a facilitator oligonucleotide. The present invention further provides compositions comprising a ribozyme having modified flanking sequences and an effective amount of a facilitator oligonucleotide.
First Claim
Family
International Classification(s)
Cited Art Landscape
Patent Citation Ranking
Advertisement
Advertisement
Advertisement
Recipient Email Address
Recipient Email Address
Comment
Recipient Email Address
Add to Portfolio(s)
To add this patent to one, or more, of your portfolios, simply click the add button.
This Patent is in these Portfolios:
Add to additional portfolios:
Last Refreshed On:
Changes done successfully