Transplacental delivery of oligonucleotides
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United States of America Patent
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Jun 10, 2003
Grant Date -
N/A
app pub date -
Oct 18, 2001
filing date -
Sep 12, 1997
priority date (Note) -
Expired
status (Latency Note)
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Abstract
This invention provides synthetic oligonucleotides that are useful for transplacental delivery, the oligonucleotides being DNA or RNA or both, preferably between 12-35 nucleotides in length, having a stabilized and charged backbone and at least one chemically modified base or sugar moiety, wherein the modified base or sugar moiety facilitates transplacental delivery.
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