Angiogenic homing molecules and conjugates derived therefrom
Number of patents in Portfolio can not be more than 2000
United States of America Patent
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Jun 10, 2003
Grant Date -
N/A
app pub date -
Sep 10, 1997
filing date -
Sep 10, 1996
priority date (Note) -
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Abstract
The present invention provides tumor homing molecules, which selectively home to a tumor. The invention also provides methods of using a tumor homing molecule to target an agent such as a drug to a selected tumor or to identify the target molecule expressed by the tumor. The invention also provides methods of targeting a tumor containing angiogenic vasculature by contacting the tumor with a molecule that specifically binds an .alpha..sub.v -containing integrin. The invention further provides molecules that can selectively home to angiogenic vasculature. In addition, the invention provides a target molecule, which is specifically bound by a tumor homing molecule and is expressed by angiogenic vasculature. The invention also provides antibodies that bind to the target molecule and peptidomimetics that competitively inhibit binding of a ligand to the target molecule.
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