Microbial production of epoxides
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United States of America Patent
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Jun 10, 2003
Grant Date -
Nov 14, 2002
app pub date -
Mar 12, 2001
filing date -
Mar 12, 2001
priority date (Note) -
Expired
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Abstract
A method for microbial production of epoxides and other oxygenated products is disclosed. The method uses a biocatalyst of methanotrophic bacteria cultured in a biphasic medium containing a major amount of a non-aqueous polar solvent. Regeneration of reducing equivalents is carried out by using endogenous hydrogenase activity together with supplied hydrogen gas. This method is especially effective with gaseous substrates and cofactors that result in liquid products.
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