Immunological control of .beta.-amyloid levels in vivo
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United States of America Patent
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Jun 24, 2003
Grant Date -
N/A
app pub date -
Jun 15, 2000
filing date -
Jun 16, 1999
priority date (Note) -
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Abstract
Disclosed are antibodies which catalyze hydrolysis of .beta.-amyloid. Antibodies generated are characterized by the amide linkage which they hydrolyze. Methods of generating the antibodies by using .beta.-amyloid peptides which incorporate transition state analogs are also provided. Also disclosed is a vectorized antibody which is characterized by the ability to cross the blood brain barrier, and is further characterized by the ability to catalyze the hydrolysis of .beta.-amyloid. The vectorized antibody can take the form of a bispecific antibody, which has a first specificity for the transferrin receptor and a second specificity for a transition state adopted by .beta.-amyloid during hydrolysis.
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