Hydrogel-forming system with hydrophobic and hydrophilic components
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United States of America Patent
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Jun 24, 2003
Grant Date -
Oct 31, 2002
app pub date -
Mar 13, 2002
filing date -
Apr 12, 1999
priority date (Note) -
Expired
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Abstract
A hydrogel forming system which comprises a hydrophobic macromer with unsaturated group terminated ends and a hydrophilic polymer which is a polysaccharide (e.g., dextran) containing hydroxy groups which are reacted with unsaturated group introducing compound, is convertible by free radical polymerization to form a hydrogel containing a three dimensional crosslinked polymer network containing hydrophobic and hydrophilic components. Agent can be entrapped in the polymer network, e.g., drugs, macromolecules or synthetic or natural polymers, for controlled release therefrom.
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