Phthalazine derivatives as phosphodiesterase 4 inhibitors
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United States of America Patent
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Jul 8, 2003
Grant Date -
N/A
app pub date -
Aug 10, 2000
filing date -
Dec 19, 1997
priority date (Note) -
Expired
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Abstract
Compounds of formula (I) wherein B is alkylene, amino, CONH or a bond; Cy is optionally substituted phenyl or heteroaryl; R is H, phenyl or (C.sub.1-4)alkyl optionally substituted; R.sub.1 is (C.sub.1-6)alkyl or polyfluoro(C.sub.1-6)-alkyl; R.sub.2 is (C.sub.4-7)cycloalkyl optionally containing an oxygen atom and optionally substituted; and the N.fwdarw.O derivatives and pharmaceutically acceptable salt thereof are PDE 4 and TNF.alpha. inhibitors. ##STR1##
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