Nucleic acid coating compositions and methods
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United States of America Patent
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Jul 22, 2003
Grant Date -
Oct 31, 2002
app pub date -
Jan 22, 2002
filing date -
Sep 22, 1998
priority date (Note) -
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Abstract
A nucleic acid coating composition including a polyanion bound, directly or through one or more intermediates, to a medical device surface, with a condensate comprising a polycation and nucleic acid bound to the polyanion, devices incorporating such coating compositions, and methods for making. In one embodiment, a silyl-heparin complex is provided, bound to a medical device surface by hydrophobic interaction with the silyl moiety, with a polycation and nucleic acid condensate bound to the heparin by electrostatic interaction.
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