Hyperpolarized helium-3 microbubble gas entrapment methods and associated products
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United States of America Patent
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Jul 29, 2003
Grant Date -
Dec 13, 2001
app pub date -
Jun 28, 2001
filing date -
Nov 3, 1998
priority date (Note) -
Expired
status (Latency Note)
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Abstract
Methods for increasing the T.sub.1 of injectable microbubble formulations of hyperpolarized .sup.3 He include the step of introducing the hyperpolarized .sup.3 He to a quantity of microbubbles held in a chamber and increasing the pressure therein to facilitate the movement or loading of the .sup.3 He into the microbubbles. Subsequently, a limited quantity of carrier liquid or a carrier liquid solution alone, or pre-mixed with .sup.3 He, can be introduced to the microbubble/.sup.3 He in the chamber to inhibit the tendency of the .sup.3 He to leach out of the bubble. Related pharmaceutical products and associated containers as well as an evacuation based method for rapid mixing and delivery of the bubbles and the .sup.3 He is also disclosed. An additional method for dissolving .sup.129 Xe gas by using bubbles as an accelerant is also described.
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