Process for preparing a multicombinatorial library of vectors for expressing antibody genes
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United States of America Patent
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Jul 29, 2003
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N/A
app pub date -
Oct 4, 1996
filing date -
Feb 10, 1994
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Abstract
On the basis of a first repertoire of genes coding for a population of one of two kinds of polypeptides capable of being combined, particularly an antibody light chain variable region, and at least one gene, and preferably a second repertoire coding for the other kind of polypeptide, particularly an antibody heavy chain variable region, the genes from the first repertoire are inserted into a first vector to form a vector population and the genes from the second repertoire are inserted into a second vector, at least one of said vectors being a recipient for the expression of both genes as polypeptides irreversibly combined with the outer surface of the product of said vector.
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