Transdermal administration of phenylpropanolamine
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United States of America Patent
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Aug 5, 2003
Grant Date -
Mar 14, 2002
app pub date -
Dec 14, 2000
filing date -
Jun 30, 2000
priority date (Note) -
Expired
status (Latency Note)
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Abstract
Methods and systems are provided for the transdermal administration of racemic phenylpropanolamine, i.e., a mixture of two or more of the four isomers of phenylpropanolamine, (+)-norephedrine, (-)-norephedrine, (+)-norpseudoephedrine, and (-)-norpseudoephedrine. Generally, the racemate will be a mixture of (+)-norephedrine and (-)-norephedrine. The racemic drug is administered along with a permeation enhancer. The permeation enhancer is preferably a basic compound, and optimally is a hydroxide-releasing agent such as sodium hydroxide.
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