Use of branched chain fatty acids and derivatives thereof for inhibition of P-glycoprotein
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United States of America Patent
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Aug 12, 2003
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N/A
app pub date -
Dec 20, 2000
filing date -
Dec 20, 2000
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Expired
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Abstract
The invention relates to the use of branched chain fatty acids (BFAs) and their derivatives for inhibition of the activity of P-glycoprotein (P-gp). In particular, the invention relates to the use of BFAs and their derivatives in the treatment of multi-drug resistant (MDR) tumors associated with increased activity of P-glycoprotein. The invention also relates to the use of the above-mentioned molecules for administration of biologically active molecules and diagnostic agents into cells associated with increased activity of P-gp, and for increasing accumulation of biologically active molecules and diagnostic agents in organs protected by biological barriers.
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