US Patent No: 6,607,658

Number of patents in Portfolio can not be more than 2000

Integrated lancing and measurement device and analyte measuring methods

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Abstract

A sensor designed to determine the amount and concentration of analyte in a sample having a volume of less than about 1 .mu.L. The sensor has a working electrode coated with a non-leachable redox mediator. The redox mediator acts as an electron transfer agent between the analyte and the electrode. In addition, a second electron transfer agent, such as an enzyme, can be added to facilitate the electrooxidation or electroreduction of the analyte. The redox mediator is typically a redox compound bound to a polymer. The preferred redox mediators are air-oxidizable. The amount of analyte can be determined by coulometry. One particular coulometric technique includes the measurement of the current between the working electrode and a counter or reference electrode at two or more times. The charge passed by this current to or from the analyte is correlated with the amount of analyte in the sample. Other electrochemical detection methods, such as amperometric, voltammetric, and potentiometric techniques, can also be used. The invention can be used to determine the concentration of a biomolecule, such as glucose or lactate, in a biological fluid, such as blood or serum. An enzyme capable of catalyzing the electrooxidation or electroreduction of the biomolecule is provided as a second electron transfer agent.

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First Claim

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Patent Owner(s)

Patent OwnerAddressTotal Patents
ABBOTT DIABETES CARE INC.ALAMEDA, CA429

International Classification(s)

  • [Classification Symbol]
  • [Patents Count]

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
FELDMAN, BENJAMIN J - 229 6792
Heller, Adam Austin, TX 508 25247
Say, James Breckenridge, CO 251 11204
Vreeke, Mark S Houston, TX 252 11821

Cited Art

Patent Info (Count) # Cites Year
 
ABBOTT LABORATORIES (4)
6,063,039 Method and apparatus for obtaining blood for diagnostic tests 204 1996
6,027,459 Method and apparatus for obtaining blood for diagnostic tests 287 1997
6,071,249 Method and apparatus for obtaining blood for diagnostic tests 246 1997
6,071,251 Method and apparatus for obtaining blood for diagnostic tests 267 1997
 
ROCHE DIAGNOSTICS OPERATIONS, INC. (4)
5,437,999 Electrochemical sensor 472 1994
5,951,492 Methods and apparatus for sampling and analyzing body fluid 329 1997
D427312 Combined blood sampling device and meter 53 1998
6,099,484 Methods and apparatus for sampling and analyzing body fluid 283 1999
 
KUDD, ARTHUR R. (2)
4,627,445 Glucose medical monitoring system 505 1985
5,279,294 Medical diagnostic system 462 1990
 
BECTON, DICKINSON AND COMPANY (1)
6,192,891 Integrated system including medication delivery pen, blood monitoring device, and lancer 257 1999
 
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (1)
5,593,852 Subcutaneous glucose electrode 495 1994
 
E. HELLER & COMPANY, INC. (1)
6,120,676 Method of using a small volume in vitro analyte sensor 535 1999
 
ELI LILLY AND COMPANY (1)
5,786,584 Vial and cartridge reading device providing audio feedback for a blood glucose monitoring system 138 1996
 
MATSUSHITA ELECTRIC INDUSTRIAL CO., LTD. (1)
5,582,697 Biosensor, and a method and a device for quantifying a substrate in a sample liquid using the same 385 1995
 
MEDISENSE, INC. (1)
5,628,890 Electrochemical sensor 563 1995
 
SANOFI-AVENTIS DEUTSCHLAND GMBH (1)
5,971,941 Integrated system and method for sampling blood and analysis 328 1997

Patent Citation Ranking

Forward Cites

Patent Info (Count) # Cites Year
 
SANOFI-AVENTIS DEUTSCHLAND GMBH (87)
7,344,894 Thermal regulation of fluidic samples within a diagnostic cartridge 4 2001
7,780,631 Apparatus and method for penetration with shaft having a sensor for sensing penetration depth 1 2001
7,041,068 Sampling module device and method 160 2002
7,025,774 Tissue penetration device 114 2002
7,749,174 Method and apparatus for lancet launching device intergrated onto a blood-sampling cartridge 2 2002
7,699,791 Method and apparatus for improving success rate of blood yield from a fingerstick 0 2002
7,682,318 Blood sampling apparatus and method 57 2002
7,537,571 Integrated blood sampling analysis system with multi-use sampling module 57 2002
7,316,700 Self optimizing lancing device with adaptation means to temporal variations in cutaneous properties 64 2002
7,344,507 Method and apparatus for lancet actuation 76 2002
7,713,214 Method and apparatus for a multi-use body fluid sampling device with optical analyte sensing 51 2002
7,708,701 Method and apparatus for a multi-use body fluid sampling device 0 2002
7,226,461 Method and apparatus for a multi-use body fluid sampling device with sterility barrier release 71 2002
7,198,606 Method and apparatus for a multi-use body fluid sampling device with analyte sensing 152 2002
7,901,362 Method and apparatus for penetrating tissue 1 2002
7,717,863 Method and apparatus for penetrating tissue 0 2002
7,674,232 Method and apparatus for penetrating tissue 55 2002
7,582,099 Method and apparatus for penetrating tissue 58 2002
7,563,232 Method and apparatus for penetrating tissue 60 2002
7,547,287 Method and apparatus for penetrating tissue 59 2002
7,524,293 Method and apparatus for penetrating tissue 58 2002
7,491,178 Method and apparatus for penetrating tissue 65 2002
7,485,128 Method and apparatus for penetrating tissue 56 2002
7,410,468 Method and apparatus for penetrating tissue 59 2002
7,374,544 Method and apparatus for penetrating tissue 83 2002
7,371,247 Method and apparatus for penetrating tissue 64 2002
7,331,931 Method and apparatus for penetrating tissue 61 2002
7,297,122 Method and apparatus for penetrating tissue 59 2002
7,291,117 Method and apparatus for penetrating tissue 60 2002
7,244,265 Method and apparatus for penetrating tissue 61 2002
7,232,451 Method and apparatus for penetrating tissue 56 2002
7,229,458 Method and apparatus for penetrating tissue 89 2002
7,258,693 Device and method for variable speed lancet 58 2003
8,267,870 Method and apparatus for body fluid sampling with hybrid actuation 1 2003
7,892,183 Method and apparatus for body fluid sampling and analyte sensing 4 2003
8,262,614 Method and apparatus for fluid injection 0 2004
7,850,621 Method and apparatus for body fluid sampling and analyte sensing 8 2004
7,604,592 Method and apparatus for a point of care device 57 2004
8,282,576 Method and apparatus for an improved sample capture device 0 2004
7,822,454 Fluid sampling device with improved analyte detecting member configuration 1 2005
8,211,037 Tissue penetration device 0 2005
8,206,317 Tissue penetration device 0 2005
8,016,774 Tissue penetration device 0 2005
7,981,055 Tissue penetration device 0 2005
7,850,622 Tissue penetration device 1 2005
8,360,991 Tissue penetration device 0 2005
8,216,154 Tissue penetration device 0 2005
8,403,864 Method and apparatus for penetrating tissue 0 2006
7,938,787 Method and apparatus for penetrating tissue 0 2006
7,909,777 Method and apparatus for penetrating tissue 0 2006
8,079,960 Methods and apparatus for lancet actuation 0 2006
8,062,231 Method and apparatus for penetrating tissue 0 2006
7,874,994 Method and apparatus for penetrating tissue 0 2006
8,007,446 Method and apparatus for penetrating tissue 0 2006
8,435,190 Method and apparatus for penetrating tissue 0 2007
7,875,047 Method and apparatus for a multi-use body fluid sampling device with sterility barrier release 0 2007
8,430,828 Method and apparatus for a multi-use body fluid sampling device with sterility barrier release 0 2007
8,382,682 Method and apparatus for penetrating tissue 0 2007
7,914,465 Method and apparatus for penetrating tissue 0 2007
7,833,171 Method and apparatus for penetrating tissue 1 2007
7,731,729 Method and apparatus for penetrating tissue 0 2007
8,414,503 Methods and apparatus for lancet actuation 0 2007
7,976,476 Device and method for variable speed lancet 0 2007
7,988,644 Method and apparatus for a multi-use body fluid sampling device with sterility barrier release 0 2007
7,901,365 Method and apparatus for penetrating tissue 7 2007
7,909,778 Method and apparatus for penetrating tissue 0 2007
8,202,231 Method and apparatus for penetrating tissue 0 2007
7,988,645 Self optimizing lancing device with adaptation means to temporal variations in cutaneous properties 1 2007
8,282,577 Method and apparatus for lancet launching device integrated onto a blood-sampling cartridge 0 2007
7,981,056 Methods and apparatus for lancet actuation 2 2007
8,123,700 Method and apparatus for lancet launching device integrated onto a blood-sampling cartridge 3 2007
7,909,775 Method and apparatus for lancet launching device integrated onto a blood-sampling cartridge 0 2007
8,197,421 Method and apparatus for penetrating tissue 0 2007
8,157,748 Methods and apparatus for lancet actuation 0 2008
8,388,551 Method and apparatus for multi-use body fluid sampling device with sterility barrier release 0 2008
7,862,520 Body fluid sampling module with a continuous compression tissue interface surface 0 2008
8,372,016 Method and apparatus for body fluid sampling and analyte sensing 0 2008
7,892,185 Method and apparatus for body fluid sampling and analyte sensing 3 2008
8,360,992 Method and apparatus for penetrating tissue 0 2008
8,366,637 Method and apparatus for penetrating tissue 0 2008
8,337,421 Tissue penetration device 0 2008
8,235,915 Method and apparatus for penetrating tissue 0 2008
8,251,921 Method and apparatus for body fluid sampling and analyte sensing 0 2010
8,296,918 Method of manufacturing a fluid sampling device with improved analyte detecting member configuration 0 2010
8,206,319 Tissue penetration device 2 2010
8,221,334 Method and apparatus for penetrating tissue 0 2010
8,382,683 Tissue penetration device 0 2012
 
ABBOTT DIABETES CARE INC. (54)
7,335,294 Integrated lancing and measurement device and analyte measuring methods 148 2003
7,976,778 Blood glucose tracking apparatus 2 2005
8,298,389 In vitro analyte sensor, and methods 0 2005
8,186,044 Method of manufacturing small volume in vitro analyte sensors 0 2007
8,231,532 Analyte monitoring device and methods of use 0 2007
7,920,907 Analyte monitoring system and method 3 2007
8,105,476 Integrated lancing and measurement device 1 2007
8,168,051 Sensor for determination of glucose 0 2007
8,117,734 Method of making an electrochemical sensor 0 2007
8,091,220 Methods of making small volume in vitro analyte sensors 0 2007
7,988,845 Integrated lancing and measurement device and analyte measuring methods 0 2008
8,114,270 Small volume in vitro analyte sensor 0 2008
7,909,984 Small volume in vitro analyte sensor 0 2008
8,142,642 Small volume in vitro analyte sensor 0 2008
7,906,009 Small volume in vitro analyte sensor 0 2008
8,255,031 Analyte monitoring device and methods of use 0 2009
8,226,555 Analyte monitoring device and methods of use 0 2009
8,162,829 Analyte monitoring device and methods of use 0 2009
8,162,830 Analyte monitoring device and methods of use 0 2009
8,346,337 Analyte monitoring device and methods of use 0 2009
8,425,758 Small volume in vitro analyte sensor and methods of making 0 2009
8,377,378 Small volume in vitro analyte sensor and methods of making 0 2009
8,372,261 Small volume in vitro analyte sensor and methods of making 0 2009
8,272,125 Method of manufacturing in vitro analyte sensors 0 2009
8,273,241 Small volume in vitro analyte sensor and methods of making 0 2009
8,268,144 Small volume in vitro analyte sensor and methods of making 0 2009
8,268,163 Small volume in vitro analyte sensor and methods of making 0 2009
8,262,996 Small volume in vitro sensor and methods of making 0 2009
8,226,815 Small volume in vitro sensor and methods of making 0 2009
8,221,685 Small volume in vitro sensor and methods of making 0 2009
8,211,363 Small volume in vitro analyte sensor and methods of making 0 2009
8,192,611 Small volume in vitro analyte sensor and methods of making 0 2009
8,187,895 Small volume in vitro analyte sensor and methods of making 0 2009
8,182,670 Small volume in vitro analyte sensor and methods of making 0 2009
8,182,671 Small volume in vitro analyte sensor and methods of making 0 2009
8,163,164 Small volume in vitro analyte sensor and methods of making 1 2009
8,153,063 Small volume in vitro analyte sensor and methods of making 0 2009
8,142,643 Small volume in vitro analyte sensor 0 2009
8,123,929 Small volume in vitro analyte sensor 0 2009
8,118,992 Small volume in vitro analyte sensor 0 2009
8,118,993 Small volume in vitro analyte sensor and methods of making 0 2009
8,114,271 Small volume in vitro analyte sensor 0 2009
8,087,162 Methods of making small volume in vitro analyte sensors 0 2009
8,083,924 Small volume in vitro analyte sensor and methods of making 0 2009
8,083,928 Small volume in vitro analyte sensor and methods of making 1 2009
8,083,929 Small volume in vitro sensor and methods of making 1 2009
8,175,673 Analyte monitoring device and methods of use 0 2009
8,235,896 Analyte monitoring device and methods of use 0 2009
8,177,716 Analyte monitoring device and methods of use 0 2009
8,268,243 Blood glucose tracking apparatus and methods 0 2009
8,226,557 Analyte monitoring device and methods of use 0 2009
8,236,242 Blood glucose tracking apparatus and methods 0 2010
8,425,743 Small volume in vitro analyte sensor and methods of making 0 2010
8,287,454 Analyte monitoring device and methods of use 0 2010
 
MEDTRONIC MINIMED, INC. (44)
7,278,983 Physiological monitoring device for controlling a medication infusion device 205 2003
7,344,500 Sensing system with auxiliary display 65 2004
7,303,543 Medication infusion set 19 2004
7,704,229 Insertion device 1 2005
7,602,310 Telemetered characteristic monitor system and method of using the same 38 2005
7,324,012 Telemetered characteristic monitor system and method of using the same 93 2005
7,713,240 Modular external infusion device 5 2005
7,725,148 Sensor with layered electrodes 0 2005
7,774,038 Real-time self-calibrating sensor system and method 2 2005
7,621,893 Methods and apparatuses for detecting occlusions in an ambulatory infusion pump 10 2005
7,942,844 Remote monitoring for networked fluid infusion systems 3 2006
7,737,581 Method and apparatus for predicting end of battery life 6 2006
7,766,873 Method and apparatus for detecting occlusions in an ambulatory infusion pump 10 2006
7,806,886 Apparatus and method for controlling insulin infusion with state variable feedback 9 2006
7,985,330 Method and system for detecting age, hydration, and functional states of sensors using electrochemical impedance spectroscopy 4 2006
8,073,008 Subnetwork synchronization and variable transmit synchronization techniques for a wireless medical device network 2 2007
8,114,268 Method and system for remedying sensor malfunctions detected by electrochemical impedance spectroscopy 1 2007
7,901,394 Physiological monitoring device for controlling a medication infusion device 23 2007
8,162,876 Medication infusion set 0 2007
7,727,148 Sensing system with auxiliary display 4 2007
8,114,269 System and method for determining the point of hydration and proper time to apply potential to a glucose sensor 1 2007
7,998,111 Methods and apparatuses for detecting occlusions in an ambulatory infusion pump 3 2008
7,882,611 Method of making an analyte sensor 13 2008
7,815,622 Modular external infusion device 4 2008
8,208,973 System and method for variable beacon timing with wireless devices 1 2008
8,348,886 Apparatus and method for controlling insulin infusion with state variable feedback 0 2009
8,070,722 Insertion device 1 2009
8,344,847 Coordination of control commands in a medical device system having at least one therapy delivery device and at least one wireless controller device 0 2009
8,182,447 Methods and apparatuses for detecting occlusions in an ambulatory infusion pump 0 2009
8,386,042 Omnidirectional accelerometer device and medical device incorporating same 0 2009
8,394,058 Insertion device 0 2010
8,152,764 Modular external infusion device 0 2010
8,192,395 System for providing blood glucose measurements to an infusion device 1 2010
8,106,534 Method and apparatus for predicting end of battery life 2 2010
8,062,257 Method and apparatus for detecting occlusions in an ambulatory infusion pump 4 2010
8,065,096 Method and apparatus for detecting occlusions in an ambulatory infusion pump 0 2010
8,249,683 Real-time self-calibrating sensor system and method 0 2010
8,348,923 Apparatus and method for controlling insulin infusion with state variable feedback 0 2010
8,182,462 Modular external infusion device 1 2010
8,105,268 Safety limits for closed-loop infusion pump control 2 2010
8,197,444 Monitoring the seating status of a fluid reservoir in a fluid infusion device 0 2010
8,267,893 Method and apparatus for detecting occlusions in an ambulatory infusion pump 0 2011
8,414,529 Insertion device 0 2011
8,414,557 Modular external infusion device 0 2012
 
ROCHE OPERATIONS LTD. (25)
7,597,793 System and method for analyte measurement employing maximum dosing time delay 2 2003
7,494,816 System and method for determining a temperature during analyte measurement 1 2003
7,488,601 System and method for determining an abused sensor during analyte measurement 6 2003
7,452,457 System and method for analyte measurement using dose sufficiency electrodes 3 2003
7,390,667 System and method for analyte measurement using AC phase angle measurements 5 2003
8,071,030 Test strip with flared sample receiving chamber 0 2004
7,829,023 Test strip with vent opening 4 2004
7,749,437 Method and reagent for producing narrow, homogenous reagent stripes 1 2004
7,727,467 Reagent stripe for test strip 5 2004
7,645,373 System and method for coding information on a biosensor test strip 1 2004
7,645,421 System and method for coding information on a biosensor test strip 3 2004
7,604,721 System and method for coding information on a biosensor test strip 6 2004
7,569,126 System and method for quality assurance of a biosensor test strip 5 2004
7,556,723 Electrode design for biosensor 2 2005
7,338,639 System and method for analyte measurement 73 2006
8,287,703 Biosensor and method of making 0 2008
7,977,112 System and method for determining an abused sensor during analyte measurement 0 2008
7,879,618 Method and reagent for producing narrow, homogenous reagent strips 0 2009
7,892,849 Reagent stripe for test strip 3 2009
8,092,668 System and method for quality assurance of a biosensor test strip 0 2009
8,083,993 System and method for coding information on a biosensor test strip 0 2009
8,119,414 Test strip with slot vent opening 0 2010
8,142,721 Test strip with slot vent opening 0 2010
8,211,379 Test strip with slot vent opening 0 2011
8,222,044 Test strip with flared sample receiving chamber 0 2011
 
DEXCOM, INC. (22)
7,519,408 Integrated receiver for continuous analyte sensor 192 2004
7,715,893 Calibration techniques for a continuous analyte sensor 98 2004
7,774,145 Transcutaneous analyte sensor 59 2006
8,133,178 Analyte sensor 1 2006
7,467,003 Dual electrode system for a continuous analyte sensor 148 2006
7,460,898 Dual electrode system for a continuous analyte sensor 143 2006
7,424,318 Dual electrode system for a continuous analyte sensor 146 2006
7,366,556 Dual electrode system for a continuous analyte sensor 146 2006
8,275,437 Transcutaneous analyte sensor 0 2007
7,761,130 Dual electrode system for a continuous analyte sensor 28 2007
7,693,560 Dual electrode system for a continuous analyte sensor 0 2007
8,160,669 Transcutaneous analyte sensor 10 2007
8,423,114 Dual electrode system for a continuous analyte sensor 0 2007
7,831,287 Dual electrode system for a continuous analyte sensor 33 2008
8,282,550 Integrated receiver for continuous analyte sensor 0 2008
7,927,274 Integrated receiver for continuous analyte sensor 17 2008
7,917,186 Calibration techniques for a continuous analyte sensor 9 2009
RE43039 Dual electrode system for a continuous analyte sensor 5 2010
8,000,901 Transcutaneous analyte sensor 15 2010
8,249,684 Calibration techniques for a continuous analyte sensor 2 2010
8,160,671 Calibration techniques for a continuous analyte sensor 4 2010
8,428,678 Calibration techniques for a continuous analyte sensor 0 2012
 
E. HELLER & COMPANY (18)
8,409,131 Analyte monitoring device and methods of use 0 2007
7,860,544 Analyte monitoring device and methods of use 4 2007
8,260,392 Analyte monitoring device and methods of use 0 2008
8,224,413 Analyte monitoring device and methods of use 0 2008
8,273,022 Analyte monitoring device and methods of use 0 2009
8,391,945 Analyte monitoring device and methods of use 0 2009
8,346,336 Analyte monitoring device and methods of use 0 2009
8,366,614 Analyte monitoring device and methods of use 0 2009
8,380,273 Analyte monitoring device and methods of use 0 2009
8,306,598 Analyte monitoring device and methods of use 0 2009
8,275,439 Analyte monitoring device and methods of use 0 2009
8,265,726 Analyte monitoring device and methods of use 0 2009
8,372,005 Analyte monitoring device and methods of use 0 2009
8,357,091 Analyte monitoring device and methods of use 0 2009
8,353,829 Analyte monitoring device and methods of use 0 2009
7,885,699 Analyte monitoring device and methods of use 3 2010
7,869,853 Analyte monitoring device and methods of use 3 2010
8,226,558 Analyte monitoring device and methods of use 0 2010
 
ROCHE DIAGNOSTICS OPERATIONS, INC. (13)
7,407,811 System and method for analyte measurement using AC excitation 7 2003
7,803,123 Lancet device having capillary action 5 2004
8,206,565 System and method for coding information on a biosensor test strip 0 2004
8,058,077 Method for coding information on a biosensor test strip 0 2004
7,718,439 System and method for coding information on a biosensor test strip 7 2004
7,214,200 Integrated analytical test element 3 2006
7,708,703 Integrated analytical test element 0 2007
8,071,384 Control and calibration solutions and methods for their use 0 2008
8,148,164 System and method for determining the concentration of an analyte in a sample fluid 0 2009
8,157,750 Integrated analytical test element 0 2010
8,257,276 Lancet device having capillary action 0 2010
8,293,538 System and method for coding information on a biosensor test strip 0 2010
8,298,828 System and method for determining the concentration of an analyte in a sample fluid 0 2012
 
BAYER HEALTHCARE LLC (4)
8,317,988 Concentration determination in a diffusion barrier layer 0 2007
8,026,104 Transient decay amperometry 0 2007
8,425,757 Gated amperometry 0 2007
8,404,100 Gated voltammetry 0 2008
 
TANDEM DIABETES CARE, INC. (3)
8,408,421 Flow regulating stopcocks and related methods 0 2008
8,287,495 Infusion pump system with disposable cartridge having pressure venting and pressure feedback 0 2011
8,298,184 Infusion pump system with disposable cartridge having pressure venting and pressure feedback 0 2011
 
LUOXIS DIAGNOSTICS, INC. (2)
8,317,997 Method and apparatus for measuring oxidation-reduction potential 0 2012
8,329,012 Method and apparatus for measuring oxidation-reduction potential 0 2012
 
NOVA BIOMEDICAL CORPORATION (2)
7,727,166 Lancet, lancet assembly and lancet-sensor combination 0 2004
7,972,281 Lancet sensor assembly and meter 0 2010
 
AVANIR PHARMACEUTICALS (1)
7,236,890 Transcutaneous analyte sensor 0 2006
 
BECTON, DICKINSON AND COMPANY (1)
7,570,980 Apparatus and method for monitoring blood glucose levels including convenient display of blood glucose value average and constituent values 0 2003
 
ELIKAN TECHNOLOGIES, INC. (1)
7,297,151 Method and apparatus for body fluid sampling with improved sensing 71 2003
 
LIFESCAN, INC. (1)
7,169,117 Integrated lance and strip for analyte measurement 56 2005
 
PANASONIC CORPORATION (1)
8,057,404 Blood sensor, blood testing apparatus, and method for controlling blood testing apparatus 0 2006
 
PELIKAN TECHNOLOGIES, INC. (1)
8,197,423 Method and apparatus for penetrating tissue 0 2010
 
PELIKEN TECHNOLOGIES, INC. (1)
7,666,149 Cassette of lancet cartridges for sampling blood 5 2002
 
PELIKON TECHNOLOGIES, INC. (1)
7,648,468 Method and apparatus for penetrating tissue 60 2002
 
OTHER [CHECK PATENT PROFILE FOR ASSIGNMENT INFORMATION] (1)
8,439,872 Apparatus and method for penetration with shaft having a sensor for sensing penetration depth 0 2010

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