Compositions and methods for inhibiting angiogenesis
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United States of America Patent
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Aug 19, 2003
Grant Date -
Jun 20, 2002
app pub date -
Oct 8, 1999
filing date -
Oct 8, 1998
priority date (Note) -
Expired
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Abstract
The invention provides for methods of reducing or inhibiting angiogenesis, tumor growth and endothelial cell proliferation by the administration of compositions containing fragments, conformations, biological equivalent, or derivatives of antithrombin III. The invention also provides for pharmaceutical compositions comprising a fragment, conformation, biological equivalent, or derivative of antithrombin III and methods of identifying novel inhibitors of tumor growth, endothelial cell proliferation, and/or angiogenesis. The invention also relates to compositions and methods for altering angiogenesis in a mammal, as well as to methods of treatment for disorders associated with angiogenesis (e.g., cancer).
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