Methods and compositions for treatment of diabetes and related conditions via gene therapy
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United States of America Patent
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Aug 19, 2003
Grant Date -
May 30, 2002
app pub date -
Mar 14, 2001
filing date -
Mar 15, 2000
priority date (Note) -
Expired
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Abstract
Disclosed are methods and compositions for treatment of diabetes, obesity and diabetic-related conditions. The methods include gene therapy based administration of a therapeutically effective amount of vectors encoding the following: glucokinase regulatory protein alone or co-administered with glucokinase or with metabolism modifying proteins; glucokinase co-administered with metabolism modifying proteins; or glucokinase regulatory protein co-administered with glucokinase in combination with metabolism modifying proteins, to a diabetic patient. Wherein the metabolism modifying proteins include UCP2, UCP3, PPAR.alpha., OB-Rb, GLP-1 and GLP-1 analogs (administered via vector or directly as a peptide). Preferred examples of GLP-1 analogs include GLP-1-Gly8, Extendin-4 and the 'Black Widow' chimeric GLP-1 analog. Additionally, PPAR.alpha. ligands and DPP-IV inhibitors may be co-administered with the above.
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